Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 99769-19-4, formula is C8H9BO4, Name is 3-(Methoxycarbonyl)phenylboronic acid. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Application of C8H9BO4.
Ge, Wei;Yang, Benhui;Chen, Lianru;Zhou, Zongtao;Jin, Yao research published 《 Discovery of Novel G-Protein-Coupled Receptor 40 Agonist with Phenylacetic Acid Scaffold for the Treatment of Type 2 Diabetes》, the research content is summarized as follows. The G-protein-coupled receptor 40 (GPR40) plays an important role in glucose-stimulated insulin secretion and therefore may be a promising anti-diabetic target. In this study, we have replaced the phenylpropionic acid of GPR40 agonist GW9508 with phenylacetic acid to avoid β-oxidation The mol. modeling study based on phenylacetic acid scaffold suggested that the present series fitted very well with the binding pocket of GPR40. Further structure-activity relationship study provided the optimal compound 6, which revealed better in vivo hypoglycemic effect than GW9508 both in normal and type 2 diabetic mice. These findings suggested that compound 6 was meaningful for further investigation and highlighted its potential as a lead compound
99769-19-4, 3-Methoxycarbonylphenylboronic acid is a useful research compound. Its molecular formula is C8H9BO4 and its molecular weight is 179.97 g/mol. The purity is usually 95%.
3-Methoxycarbonylphenylboronic acid is a reactanct that has been involved in a variety of applications. For instance, it has been used in Suzuki-Miyaura cross-coupling, Iterative cross-coupling of boronate building blocks, cross-coupling with aryl/ alkenyl sulfonates, synthesis of symmetrical biaryls via CuCl catalyzed homocoupling, trifluoromethylation, and cyanation just to name a few of its many uses.
3-Methoxycarbonylphenylboronic acid is a boronate ligand that has been shown to have an interaction with the nitrogen atoms in amines. This compound is used for the Suzuki coupling reaction, which is a chemical reaction between an organoboron compound and an organic electrophile. 3-Methoxycarbonylphenylboronic acid has a helical structure that can be seen by FTIR spectroscopy and it has potent inhibitory activity., Application of C8H9BO4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics