Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 870-50-8, formula is C10H18N2O4, Name is Di-tert-butyl diazene-1,2-dicarboxylate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. SDS of cas: 870-50-8.
Garrison, Aaron T.;Orsi, Douglas L.;Capstick, Rory A.;Whomble, David;Li, Jinming;Carter, Trever R.;Felts, Andrew S.;Vinson, Paige N.;Rodriguez, Alice L.;Han, Allie;Hajari, Krishma;Cho, Hyekyung P.;Teal, Laura B.;Ragland, Madeline G.;Ghamari-Langroudi, Masoud;Bubser, Michael;Chang, Sichen;Schnetz-Boutaud, Nathalie C.;Boutaud, Olivier;Blobaum, Anna L.;Foster, Daniel J.;Niswender, Colleen M.;Conn, P. Jeffrey;Lindsley, Craig W.;Jones, Carrie K.;Han, Changho research published 《 Development of VU6019650: A Potent, Highly Selective, and Systemically Active Orthosteric Antagonist of the M5 Muscarinic Acetylcholine Receptor for the Treatment of Opioid Use Disorder》, the research content is summarized as follows. The muscarinic acetylcholine receptor (mAChR) subtype 5 (M5) represents a novel potential target for the treatment of multiple addictive disorders, including opioid use disorder. Through chem. optimization of several functional high-throughput screening hits, VU6019650 (27b)(I) was identified as a novel M5 orthosteric antagonist with high potency (human M5 IC50 = 36 nM), M5 subtype selectivity (>100-fold selectivity against human M1-4) and favorable physicochem. properties for systemic dosing in preclin. addiction models. In acute brain slice electrophysiol. studies, 27b blocked the nonselective muscarinic agonist oxotremorine-M-induced increases in neuronal firing rates of midbrain dopamine neurons in the ventral tegmental area, a part of the mesolimbic dopaminergic reward circuitry. Moreover, 27b also inhibited oxycodone self-administration in male Sprague-Dawley rats within a dose range that did not impair general motor output.
870-50-8, Di-tert-butyl azodicarboxylate, also known as Di-tert-butyl azodicarboxylate, is a useful research compound. Its molecular formula is C₁₀H₁₈N₂O₄ and its molecular weight is 230.26 g/mol. The purity is usually 95%.
Di-tert-butyl azodicarboxylate is a reagent used in the electrophilic amination of β-keto esters catalyzed by an axially chiral guanidine. Building block in an enantioselective synthesis of 3,6-dihyropyridazines employing organocatalysts such a L-proline or (S)-2-pyrrolidinyl tetrazole. Utilized in the asymmetric Friedel-Crafts amination via a chiral organocatalyst.
Di-tert-butyl azodicarboxylate is a reagent used in the preparation of acyl hydrazinedicarboxylates via photoorganocatalytic hydroacylation of dialkyl azodicarboxylates with aldehydes in presence of phenylglyoxylic acid as photocatalyst., SDS of cas: 870-50-8
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics