Sreedharan, Ramdas;Rajeshwaran, Purushothaman;Panyam, Pradeep Kumar Reddy;Yadav, Saurabh;Nagaraja, C. M.;Gandhi, Thirumanavelan published 《Acylation of oxindoles using methyl/phenyl esters via the mixed Claisen condensation-an access to 3-alkylideneoxindoles》 in 2020. The article was appeared in 《Organic & Biomolecular Chemistry》. They have made some progress in their research.COA of Formula: C9H10O2 The article mentions the following:
Herein, simple acyl sources, viz. Me and Ph esters, which acylate oxindoles via the mixed Claisen condensation are reported. This straightforward protocol is mediated by LiHMDS and KOtBu and successfully applied to a wide range of substrates. It is a noteworthy transformation that skips the stepwise generation of enolates and acylation, and the reaction is performed at a moderate temperature with no side reactions. This protocol produces the first examples of ortho-substituents in an aryl ring flanked with electron-donating and electron-withdrawing substrates. Interestingly, robust organometallic ferrocenyl Me ester cleaved under these conditions with ease. Furthermore, biol. important Tenidap’s analog was synthesized by this protocol. The experimental procedure involved many compounds, such as Methyl 3-methylbenzoate (cas: 99-36-5) .
Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester. Esters are widespread in nature and are widely used in industry. Several billion kilograms of polyesters are produced industrially annually, important products being polyethylene terephthalate, acrylate esters, and cellulose acetate.COA of Formula: C9H10O2
Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics