Application In Synthesis of 1-Phenylethyl acetate《CO2-expanded bio-based liquids as novel solvents for enantioselective biocatalysis》 was published in 2017. The authors were Hoang, Hai Nam;Nagashima, Yoshihiro;Mori, Shuichi;Kagechika, Hiroyuki;Matsuda, Tomoko, and the article was included in《Tetrahedron》. The author mentioned the following in the article:
For the first time, CO2-expanded bio-based liquids were reported as novel and sustainable solvents for biocatalysis. Herein, it was found that by expansion with CO2, 2-methyltetrahydrofuran (MeTHF), and other bio-based liquids, which were not favorable solvents for immobilized Candida antarctica lipase B (Novozym 435) catalyzed transesterification, were tuned into excellent reaction media. Especially, for the kinetic resolution of challenging bulky secondary substrates such as rac-1-adamantylethanol, the lipase displayed very high activity with excellent enantioselectivity (E value > 200) in CO2-expanded MeTHF (MeTHF concentration 10% volume/volume, 6 MPa), whereas there was almost no activity observed in conventional organic solvents. To complete the study, the researchers used 1-Phenylethyl acetate (cas: 93-92-5) .
1-Phenylethyl acetate(cas:93-92-5) is a carboxylic ester. Application In Synthesis of 1-Phenylethyl acetate It may be prepared by acetylation of methyl phenyl carbinol; from benzaldehyde by reacting with magnesium methyl bromide and subsequent acetylation; from 1-bromoethylbenzene and silver acetate in acetic acid.
Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics