Ari, Ferda;Ulukaya, Engin;Oran, Seyhan;Celikler, Serap;Ozturk, Sule;Ozel, Mustafa Zafer published 《Promising anticancer activity of a lichen, Parmelia sulcata Taylor, against breast cancer cell lines and genotoxic effect on human lymphocytes》 in 2015. The article was appeared in 《Cytotechnology》. They have made some progress in their research.Application In Synthesis of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate The article mentions the following:
Plants are still to be explored for new anti-cancer compounds because overall success in cancer treatment is still not satisfactory. As a new possible source for such compounds, the lichens are recently taking a great attention. We, therefore, explored both the genotoxic and anti-growth properties of lichen species Parmelia sulcata Taylor. The chem. composition of P. sulcata was analyzed with comprehensive gas chromatog.-time of flight mass spectrometry. Anti-growth effect was tested in human breast cancer cell lines (MCF-7 and MDA-MB-231) by the MTT and ATP viability assays, while the genotoxic activity was studied by assays for micronucleus, chromosomal aberration and DNA fragmentation in human lymphocytes culture. Cell death modes (apoptosis/necrosis) were morphol. assessed. P. sulcata inhibited the growth in a dose-dependent manner up to a dose of 100 μg/mL and induced caspase-independent apoptosis. It also showed genotoxic activity at doses (>125 μg/mL) higher than that required for apoptosis. These results suggest that P. sulcata may induce caspase-independent apoptotic cell death at lower doses, while it may be genotoxic at relatively higher doses.Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) were involved in the experimental procedure.
Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.Application In Synthesis of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate
Reference:
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