Phatake, Ravindra S.;Nechmad, Noy B.;Reany, Ofer;Lemcoff, N. Gabriel published 《Highly Substrate-Selective Macrocyclic Ring Closing Metathesis》. The research results were published in《Advanced Synthesis & Catalysis》 in 2022.Product Details of 106-02-5 The article conveys some information:
A selective ring-closing metathesis (RCM) reaction for the formation of large macrocycles, e.g., I by using latent sulfur chelated ruthenium iodide benzylidenes, readily activated by thermal and photochem. (UV-A and visible light) stimuli, is reported. For dienes, e.g., (E)-Henicosa-1,19-dien-10-one having one terminal alkene and one internal double bond, the specific affinity of diiodo ruthenium alkylidenes for the unhindered terminus, combined with their reluctance to react with internal olefins, favors RCM over oligomerization, providing high macrocyclic yields even at relatively high concentrations Alternatively, for substrates containing two internal double bonds, a sacrificial methylene donor can be used to obtain the desired products. With this methodol., lactones, lactams, and macrocyclic ketones ranging from 13- to 22-membered rings could be synthesized in moderate to high yields. In addition, synthetic applications for a one-pot cyclization/reduction sequence to produce Exaltolide, a natural macrolide (com. musk), Dihydrocivetone, and other saturated macrocycles have been explored. An important advantage for diiodo ruthenium benzylidene catalysts over their less selective dichloro counterparts provides a more profound understanding of the mechanisms that provide the enhanced cyclization outcome. And Oxacyclohexadecan-2-one (cas: 106-02-5) was used in the research process.
Oxacyclohexadecan-2-one(cas:106-02-5) is a natural product found in Lonicera japonica and Angelica archangelica.Product Details of 106-02-5 It is a macrocyclic lactone that can be used as a flavoring agent and fragrance ingredient due to its musk flavor/odor.
Reference:
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