Pham, Ly L.;Truong, Lisa;Ouedraogo, Gladys;Loisel-Joubert, Sophie;Martin, Matthew T.;Paul Friedman, Katie published 《Profiling 58 compounds including cosmetic-relevant chemicals using ToxRefDB and ToxCast》. The research results were published in《Food and Chemical Toxicology》 in 2019.Name: 1-Phenylethyl acetate The article conveys some information:
This work suggests that NAMs for bioactivity may inform a conservative point-of-departure estimate for diverse CRCs. For 17 of the 58 CRCs, high-throughput toxicokinetic data were used to calculate administered equivalent doses (AEDs) in mg/kg/day units for the in vitro bioactivity observed, and these AEDs served as conservative estimators of the systemic LELs observed in vivo. In terms of both target organ effects and study type, the median of the lowest effect level (LEL) doses in ToxRefDB for CRCs tended to be slightly higher than the median for the remaining 928 chems. with study data in ToxRefDB, though the ranges of LELs were similar. CRCs were diverse in use types as suggested by broad chem. use categories. To demonstrate NAMs for safety assessment, we surveyed in vitro bioactivity and in vivo systemic toxicity data in the US Environmental Protection Agency’s (EPA’s) Toxicity Forecaster (ToxCast) and Toxicity Reference databases (ToxRefDB), resp., for 58 chems. identified as CRCs, including cosmetic ingredients as well as trace contaminants. Safety assessment for cosmetic-relevant chems. (CRCs) in the European Union has been reshaped by restrictions on animal testing, and new approach methodologies (NAMs) for predicting toxicity are critical to ensure new cosmetic product safety. The experimental procedure involved many compounds, such as 1-Phenylethyl acetate (cas: 93-92-5) .
1-Phenylethyl acetate(cas:93-92-5) is a carboxylic ester. Name: 1-Phenylethyl acetate It may be prepared by acetylation of methyl phenyl carbinol; from benzaldehyde by reacting with magnesium methyl bromide and subsequent acetylation; from 1-bromoethylbenzene and silver acetate in acetic acid.
Reference:
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