Ji, Peng;Li, Chen-chen;Wei, Yan-ming;Hua, Yong-li;Yao, Wan-ling;Wu, Fan-lin;Zhang, Xiao-song;Yuan, Zi-wen;Zhao, Nian-shou;Zhang, Ya-hui;Wen, Yan-qiao published 《A new method providing complementary explanation of the blood-enriching function and mechanism of unprocessed Angelica sinensis and its four kinds of processed products based on tissue-integrated metabolomics and confirmatory analysis》 in 2022. The article was appeared in 《Biomedical Chromatography》. They have made some progress in their research.Product Details of 112-62-9 The article mentions the following:
Angelica sinensis (AS) is a common Traditional Chinese Medicine used for tonifying blood in China. Unprocessed AS and its four kinds of processed products (ASs) are used to treat blood deficiency syndrome in the country. The different blood-tonifying mechanisms of ASs remain unclear. In this work, a novel method integrating metabolomics and hematol. and biochem. parameters was established to provide a complementary explanation of blood supplementation mechanism of ASs. Our results revealed that different ASs exhibited various blood supplementation effect, and that AS parched with alc. demonstrated the best blood supplementation effect. Eight metabolites from liver tissue and 12 metabolites from spleen tissue were considered to be potential biomarkers. These biomarkers were involved in four metabolic pathways. Correlation anal. results showed that L-aspartic acid and L-alanine (spleen tissue), linoleic acid, and L-cystathionine (liver tissue) exhibited a high pos. or neg. correlation with the aforesaid biochem. indicators. The blood-supplementation effect mechanism of ASs were related to four metabolic pathways. L-Aspartic acid and L-alanine (spleen tissue), linoleic acid, and L-cystathionine (liver tissue) were the four key metabolites associated with the blood supplementation effect of ASs. This study gives a complementary explanation of the blood supplementation effect and mechanism of action of ASs. The experimental procedure involved many compounds, such as Methyl oleate (cas: 112-62-9) .
Methyl oleate(cas: 112-62-9) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of oleic acid with methanol.Product Details of 112-62-9 It is also used in biochemical research as a chromatographic reference standard.
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