Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Electric Literature of 87-13-8.
Al-Sanea, Mohammad M.;Elkamhawy, Ahmed;Paik, Sora;Lee, Kyeong;El Kerdawy, Ahmed M.;Syed Nasir Abbas, Bukhari;Joo Roh, Eun;Eldehna, Wagdy M.;Elshemy, Heba A. H.;Bakr, Rania B.;Ali Farahat, Ibrahim;Alzarea, Abdulaziz I.;Alzarea, Sami I.;Alharbi, Khalid S.;Abdelgawad, Mohamed A. research published 《 Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA/B) inhibitors: Synthesis, biological evaluation and in silico insights》, the research content is summarized as follows. Aiming at the development of novel chemotype of dual AURKA/B inhibitors, design and synthesis of three series of 4-anilinoquinoline derivatives I [R = H, 6-Br, 6-Me, 5,7-di-Cl; R1 = NH2, HNMe, O2SMe; X = NH, SO2] bearing a sulfonamide moiety was reported. The % inhibition of AURKA/B was determined for all target quinolines I, then compounds I showed more than 50% inhibition on either of the enzymes, were evaluated further for their IC50 on the corresponding enzyme. In particular, compound I [R = 5,7-di-Cl; R1 = HNMe; X = SO2] displayed potent AURKA/B inhibitory activities with IC50 of 0.93 and 0.09μM, resp. Also, I [R = 5,7-di-Cl; R1 = HNMe; X = SO2] emerged as the most efficient anti-proliferative analog in the US-NCI anticancer assay toward the NCI 60 cell lines panel, with broad spectrum activity against different cell lines from diverse cancer subpanels. Docking studies, confirmed that, the sulfonamide SO2 oxygen was involved in a hydrogen bond with Lys162 and Lys122 in AURKA and AURKB, resp., whereas, the sulfonamide NH could catch hydrogen bond interaction with the surrounding amino acid residues Lys141, Glu260, and Asn261 in AURKA and Lys101, Glu177, and Asp234 in AURKB. Furthermore, N1 nitrogen of the quinoline scaffold formed an essential hydrogen bond with the hinge region key amino acids Ala213 and Ala173 in AURKA and AURKB, resp.
Electric Literature of 87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.
Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics