In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of 3,3-disubstituted oxindoles through Pd-catalyzed intramolecular cyanoamidation, published in 2010-03-13, which mentions a compound: 415918-91-1, mainly applied to vinylphenyl cyanoformamide preparation palladium catalyst intramol cyanoamidation; oxindole derivative preparation; palladium chiral binaphthyl phosphoramidite ligand stereoselective cyanoamidation catalyst, Category: esters-buliding-blocks.
The intramol. cyanoamidation of olefins was achieved. When N-(2-vinylphenyl)cyanoformamides, e.g., I, were treated with a palladium catalyst, intramol. cyanoamidation took place to give the corresponding 3,3-disubstituted oxindoles, e.g., II. P(t-Bu)3 showed a remarkable effect on this reaction; when it was used with Pd(dba)2, the reaction was completed in 15 min at 100° for many substrates. Furthermore, enantioselective cyanoamidation was accomplished with Pd(dba)2 and an optically active phosphoramidite to provide optically active 3,3-disubstituted oxindoles. Manipulation of the resulting oxindoles has been studied.
《Synthesis of 3,3-disubstituted oxindoles through Pd-catalyzed intramolecular cyanoamidation》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine)Category: esters-buliding-blocks.
Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics