The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Bromo-8-methylquinoline( cas:178396-31-1 ) is researched.Recommanded Product: 6-Bromo-8-methylquinoline.Sen, Malay; Emayavaramban, Balakumar; Barsu, Nagaraju; Premkumar, J. Richard; Sundararaju, Basker published the article 《Cp*Co(III)-Catalyzed C(sp3)-H Bond Activation: A Highly Stereoselective and Regioselective Alkenylation of 8-Methylquinoline with Alkynes》 about this compound( cas:178396-31-1 ) in ACS Catalysis. Keywords: methylquinoline alkyne cobalt stereoselective regioselective alkenylation catalyst; olefin trisubstituted stereoselective preparation. Let’s learn more about this compound (cas:178396-31-1).
Efficient, atom-economical, highly regioselective C(sp3)-H bond alkenylation of 8-methylquinoline catalyzed by (Cp*)Co(III) is reported. A well-defined, air-stable, mol. cobalt catalyst, Cp*Co(III), is employed for the first time in C(sp3)-H bond activation. The developed methodol. is broadly applicable and tolerates a variety of functional groups, under mild conditions. Exptl. and d. functional theory (DFT) results suggest that the initial cyclometalation was occurred via an external-base-assisted concerted metalation deprotonation pathway.
The article 《Cp*Co(III)-Catalyzed C(sp3)-H Bond Activation: A Highly Stereoselective and Regioselective Alkenylation of 8-Methylquinoline with Alkynes》 also mentions many details about this compound(178396-31-1)Recommanded Product: 6-Bromo-8-methylquinoline, you can pay attention to it, because details determine success or failure
Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics