Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II), is researched, Molecular C6H12N2O4Pt, CAS is 41575-94-4, about Outpatient fractionated ICE protocol in relapsed/refractory lymphomas: Efficacy and safety.Recommanded Product: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II).
Methods: In this retrospective trial, we analyzed data of patients with relapsed/refractory lymphoma who received outpatient fractionated ICE between 2011-2017 at a tertiary care center. The three weekly ICE protocol consisted of: ifosfamide 1500 mg/m2 infused over 2 h on days 1-3, carboplatin (5 AUC) on day 1, and etoposide 100 mg/m2 on days 1-3. Rituximab 375 mg/m2 was given to patients with CD20 pos. B cell Non-Hodgkin lymphoma. Results: Total of 89 patients were included in this research project. Majority of patients had Hodgkin lymphoma (64%). Mean number of ICE cycles received was 2.5. Complete remission and partial remission rates for primary refractory (62.9%) and non-primary refractory (36.4%) disease were 10.5% and 26.3% vs. 41.9% and 29.0% resp. Event free survival rate was 14.5 mo (95% CI 7.7-28.0) and overall survival rate 88.7 mo (95% CI 48.1-NR). Grade 3 hematol. toxicities were documented in 19.1% of patients with 10.1% experiencing neutropenia and 9% thrombocytopenia. 5.6% had febrile neutropenia. Conclusions: Our study included, to our knowledge, the largest number of patients treated with outpatient fractionated ICE. Results demonstrated that this regimen might be a reasonable replacement for classic ICE regimen in many patients with lymphoma. It has a favorable safety profile. However, patients with primary refractory lymphomas need more effective regimens.
Different reactions of this compound(cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II))Recommanded Product: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II) require different conditions, so the reaction conditions are very important.
Reference:
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