Application of 178396-31-1. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 6-Bromo-8-methylquinoline, is researched, Molecular C10H8BrN, CAS is 178396-31-1, about Cp*RhIII-Catalyzed Sterically Controlled C(sp3)-H Selective Mono- and Diarylation of 8-Methylquinolines with Organoborons. Author is Kumar, Rakesh; Parmar, Diksha; Gupta, Shiv Shankar; Chandra, Devesh; Dhiman, Ankit Kumar; Sharma, Upendra.
The Cp*Rh(III)-catalyzed regioselective and chemoselective C-H arylation of 8-methylquinolines with organoboron reagents were disclosed to give quinoline derivatives I [R = H, 5-Me, 7-Cl, etc.; R1 = H, Ph, 4-ClC6H4, etc.; R2 = Ph, 4-MeOC6H4, 4-ClC6H4, etc.]. Late-stage monoarylation of oxime derivative santonin gave corresponding monoarylated oxime derivative II and gram-scale synthesis of compound I [R = 7-Cl; R1 = H; R2 = 4-ClC6H4] was also been carried out. A mechanistic study revealed that the current reaction was first order with respect to both reactants and a five-membered rhodacycle intermediate may be involved in the catalytic cycle.
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Reference:
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