In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Outcomes of prophylactic cranial irradiation in patients with small cell lung cancer in the modern era of baseline magnetic resonance imaging of the brain, published in 2022, which mentions a compound: 41575-94-4, mainly applied to prophylactic cranial irradiation human lung cancer brain magnetic imaging; Small-cell lung cancer; prophylactic cranial irradiation; brain magnetic resonance imaging; brain metastases; limited-stage small-cell lung cancer; extensive-stage small-cell lung cancer, Application In Synthesis of cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II).
For decades many patients with small cell lung cancer (SCLC) have been offered prophylactic cranial irradiation (PCI) to prevent brain metastases (BM). However, the role of PCI is debated in the modern era of increased brain magnetic resonance imaging (MRI) availability. BM in SCLC patients may respond to chemotherapy, and if a neg. MRI is used in the decision to use of PCI in the treatment strategy, the timing of brain MRI may be crucial when evaluating the effect of PCI. This retrospective study investigates the impact of PCI outcomes in patients with SCLC staged with brain MRI prior to chemotherapy. This study included 245 patients diagnosed SCLC/mixed NSCLC-SCLC treated between 2012 and 2019. The population was analyzed sep. for limited disease (LS-SCLC) and extensive disease (ES-SCLC). Patients were divided into groups based on baseline brain MRI prior to chemotherapy and PCI. The primary endpoint was time to symptomatic BM. Secondary endpoints were overall survival (OS), and progression-free survival (PFS). In patients with LS-SCLC staged with brain MRI the probability of developing symptomatic BM at one year was 4% vs. 22% (p < 0.05), median OS was 55 vs. 24 mo (p < 0.05), and median PFS was 30 vs. 10 mo (p < 0.05) with and without PCI, resp. No differences in probability of symptomatic BM and survival outcomes were observed in ES-SCLC. In a multivariate regression anal., no variables were statistically significant associated with the risk of developing symptomatic BM in patients with LS-SCLC and ES-SCLC. For patients with ES-SCLC staged with brain MRI, PS (HR = 3.33, CI; 1.41-7.89, p < 0.05) was associated with poor survival. This study found that PCI in LS-SCLC patients staged with brain MRI had lower incidence of symptomatic BM and improved survival outcomes suggesting PCI as standard of care. Similar benefit of PCI in patients with ES-SCLC was not found. There are many compounds similar to this compound(41575-94-4)Application In Synthesis of cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II). if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.
Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics