The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Bromo-8-methylquinoline( cas:178396-31-1 ) is researched.Application of 178396-31-1.Chen, Lijin; Zhou, Zhenfei; Zhang, Saifei; Li, Xiaoqian; Ma, Xuebing; Dong, Jiaxing published the article 《Palladium(II)-catalyzed oxidative C(sp3)-P bond formation via C(sp3)-H bond activation》 about this compound( cas:178396-31-1 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: quinoline phosphonate phosphinate phosphine oxide preparation CH activation copuling; oxidative coupling secondary phosphinyl compound methylquinoline preparation phosphonate phosphinate. Let’s learn more about this compound (cas:178396-31-1).
8-Methylquinolines undergo side-chain C-H-activation and phosphinylation in palladium-catalyzed oxidative coupling with secondary phosphinyl compounds, phosphonates, phosphinates and phosphine oxides X2P(O)H, forming the corresponding 8-phosphinylmethylquinolines 8-X2P(O)CH2[C9H6-nN]Rn (X = alkoxy, aryl; R = H, halo, Me, aryl, NO2, alkenyl, alkynyl). Disclosed herein is a Pd(II)-catalyzed C(sp3)-H/P-H oxidative cross-coupling reaction between 8-methylquinolines with H-phosphonates or diarylphosphine oxides via chelation-assisted C(sp3)-H bond activation. The protocol exhibits a relatively broad functional-group tolerance and exclusive chemo- and regioselectivity. Furthermore, detailed mechanistic studies support the proposed reaction pathway.
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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics