In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Non-stabilized nucleophiles in Cu-catalysed dynamic kinetic asymmetric allylic alkylation, published in 2015-01-15, which mentions a compound: 415918-91-1, mainly applied to copper catalyzed dynamic kinetic asym transformation racemic substrate; unstabilized nucleophile dynamic kinetic asym allylic alkylation mechanism; organometallic reagent preparation dynamic kinetic asym allylic alkylation; medicinal tuberculosis leprosy preparation; aminobenzoate biosynthesis inhibitor preparation, Reference of (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine.
The development of new reactions forming asym. carbon-carbon bonds has enabled chemists to synthesize a broad range of important carbon-containing mols., including pharmaceutical agents, fragrances and polymers. Most strategies to obtain enantiomerically enriched mols. rely on either generating new stereogenic centers from prochiral substrates or resolving racemic mixtures of enantiomers. An alternative strategy-dynamic kinetic asym. transformation-involves the transformation of a racemic starting material into a single enantiomer product, with greater than 50 per cent maximum yield. The use of stabilized nucleophiles (pKa < 25, where Ka is the acid dissociation constant) in palladium-catalyzed asym. allylic alkylation reactions has proved to be extremely versatile in these processes. Conversely, the use of non-stabilized nucleophiles in such reactions is difficult and remains a key challenge. Here we report a copper-catalyzed dynamic kinetic asym. transformation using racemic substrates and alkyl nucleophiles. These nucleophiles have a pKa of ≥50, more than 25 orders of magnitude more basic than the nucleophiles that are typically used in such transformations. Organometallic reagents are generated in situ from alkenes by hydrometallation and give highly enantioenriched products under mild reaction conditions. The method is used to synthesize natural products that possess activity against tuberculosis and leprosy, and an inhibitor of para-aminobenzoate biosynthesis. Mechanistic studies indicate that the reaction proceeds through a rapidly isomerizing intermediate. We anticipate that this approach will be a valuable complement to existing asym. catalytic methods. Here is just a brief introduction to this compound(415918-91-1)Reference of (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, more information about the compound((11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine) is in the article, you can click the link below.
Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics