The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)(SMILESS: O=C1C2(CCC2)C(O[Pt]O1)=O.N.N,cas:41575-94-4) is researched.Category: benzofurans. The article 《Platinum Doublet plus Atezolizumab as First-line Treatment in Metastatic Large Cell Neuroendocrine Carcinoma: A Single Institution Experience》 in relation to this compound, is published in Cancer Investigation. Let’s take a look at the latest research on this compound (cas:41575-94-4).
Large Cell Neuroendocrine Carcinoma of the Lung (L-LCNEC) is a rare type of neuroendocrine lung cancer that is increasingly diagnosed. However, the optimal management regarding the advanced stage is unclear. The purpose of this article is to present and compare our experience when L-LCNEC is treated as Small Cell Lung Cancer (SCLC). Overall, eight cases of L-LCNEC were included. We retrospectively reviewed medical files and reports by accessing the Institution’s Data of patients diagnosed with L-LCNEC from Apr. 2019 until Dec. 2020 and evaluated their response to the combination of Platinum – Etoposide – Atezolizumab as first-line chemotherapy. The overall observed response rate (ORR) of 75%. The median PFS was 6.85 mo. The median response duration was 5.5 mo. Comparing our findings with other retrospective and prospective studies, it seems that the systematic treatment of choice and management in L-LCNEC of the lung should be that of a small cell carcinoma of the lung.
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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics