The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)(SMILESS: O=C1C2(CCC2)C(O[Pt]O1)=O.N.N,cas:41575-94-4) is researched.Synthetic Route of C36H30NO2P. The article 《First-in-human phase 1 study of budigalimab, an anti-PD-1 inhibitor, in patients with non-small cell lung cancer and head and neck squamous cell carcinoma》 in relation to this compound, is published in Cancer Immunology Immunotherapy. Let’s take a look at the latest research on this compound (cas:41575-94-4).
Budigalimab is a humanized, recombinant IgG1 monoclonal antibody targeting programmed cell death protein 1 (PD-1). We present the safety, efficacy, pharmacokinetic (PK), and pharmacodynamic data from patients enrolled in the head and neck squamous cell carcinoma (HNSCC) and non-small cell lung cancer (NSCLC) expansion cohorts of the phase 1 first-in-human study of budigalimab monotherapy (NCT03000257; registered 15 Dec. 2016). Patients with recurrent/metastatic HNSCC or locally advanced/metastatic NSCLC naive to PD-1/PD-1-ligand inhibitors were enrolled; patients were not selected on the basis of oncogene driver mutations or PD-L1 status. Budigalimab was administered at 250 mg i.v. Q2W or 500 mg i.v. Q4W until disease progression/unacceptable toxicity. The primary endpoints were safety and PK; the secondary endpoint was efficacy. Exploratory endpoints included biomarker assessments. In total, 81 patients were enrolled (HNSCC: N = 41 [PD-L1 pos.: n = 19]; NSCLC: N = 40 [PD-L1 pos.: n = 16]); median treatment duration was 72 days (range, 1-617) and 71 days (range, 1-490) for the HNSCC and NSCLC cohorts, resp. The most frequent grade ≥ 3 treatment-emergent adverse event was anemia (HNSCC: n = 9, 22%; NSCLC: n = 5, 13%). Both dosing regimens had comparable drug exposure and increased interferon gamma-induced chemokines, monokine induced by gamma interferon, and interferon-gamma-inducible protein 10. Objective response rates were 13% (90% CI, 5.1-24.5) in the HNSCC cohort and 19% (90% CI, 9.2-32.6) in the NSCLC cohort. Median progression-free survival was 3.6 mo (95% CI, 1.7-4.7) and 1.9 mo (95% CI, 1.7-3.7) in the HNSCC and NSCLC cohorts. The safety, efficacy and biomarker profiles of budigalimab are similar to other PD-1 inhibitors. Development of budigalimab in combination with novel anticancer agents is ongoing.
There is still a lot of research devoted to this compound(SMILES：O=C1C2(CCC2)C(O[Pt]O1)=O.N.N)Formula: C6H12N2O4Pt, and with the development of science, more effects of this compound(41575-94-4) can be discovered.
Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics