The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)( cas:41575-94-4 ) is researched.Recommanded Product: 41575-94-4.Alderuccio, Juan Pablo; Kuker, Russ A.; Barreto-Coelho, Priscila; Martinez, Bianca M.; Miao, Feng; Kwon, Deukwoo; Beitinjaneh, Amer; Wang, Trent P.; Reis, Isildinha M.; Lossos, Izidore S.; Moskowitz, Craig H. published the article 《Prognostic value of presalvage metabolic tumor volume in patients with relapsed/refractory diffuse large B-cell lymphoma》 about this compound( cas:41575-94-4 ) in Leukemia & Lymphoma. Keywords: diagnostic agent metabolic tumor volume diffuse large Bcell lymphoma; Diffuse large B-cell lymphoma; metabolic tumor volume; platinum-based chemotherapy. Let’s learn more about this compound (cas:41575-94-4).
Identification of new prognostic factors in relapsed/refractory (rel/ref) diffuse large B-cell lymphoma (DLBCL) is essential for developing risk-adapted approaches. We retrospectively analyzed prognostication based on metabolic tumor volume (MTV) in rel/ref DLBCL (n = 108) before platinum-based salvage chemotherapy. Using 41% SUVmax threshold, patients achieving complete response (CR) exhibited significantly lower baseline values of MTV, compared to those achieving partial response (PR) or with progression of disease (medians MTV 16.26 vs. 72.51 vs. 98.11 mL, resp.). As a continuous variable, log2(MTV) was predictive of failure to achieve CR (1-unit increase odds ratio [OR] = 1.58, p < 0.001). Log2(MTV) significantly predicted progression-free survival (PFS) and overall survival (OS), and one-unit increase in log2(MTV) was associated with shorter PFS (hazard ratio [HR] = 1.12, p = 0.035) and OS (HR = 1.17, p = 0.007). However, heterogeneity in the selection of post-salvage chemotherapy approaches may have affected survival. These data demonstrate the ability of presalvage MTV to discriminate responders from non-responders to platinum-based chemotherapy and predict survival. Here is a brief introduction to this compound(41575-94-4)Recommanded Product: 41575-94-4, if you want to know about other compounds related to this compound(41575-94-4), you can read my other articles.
Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics