The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Bromo-8-methylquinoline( cas:178396-31-1 ) is researched.Recommanded Product: 6-Bromo-8-methylquinoline.Kumar, Rohit; Kumar, Rakesh; Parmar, Diksha; Gupta, Shiv Shankar; Sharma, Upendra published the article 《Ru(II)/Rh(III)-Catalyzed C(sp3)-C(sp3) Bond Formation through C(sp3)-H Activation: Selective Linear Alkylation of 8-Methylquinolines and Ketoximes with Olefins》 about this compound( cas:178396-31-1 ) in Journal of Organic Chemistry. Keywords: alkylquinoline alkylsantonin oxime regioselective preparation; ruthenium rhodium catalyst regioselective alkylation methylquinoline acrylate styrene alkene; regioselective alkylation methylquinoline santonin oxime ether alkene ruthenium catalyst; rhodium catalyst regioselective alkylation methylquinoline santonin oxime ether alkene; mechanism kinetic isotope effect regioselective alkylation methylquinoline acrylate. Let’s learn more about this compound (cas:178396-31-1).
In the presence of either [RuCl2(p-cymene)]2 or [Cp*RhCl2]2 and AgSbF6, 8-methylquinolines underwent regioselective alkylation with acrylates, styrenes, and other alkenes mediated by pivalic acid in hexafluoroisopropanol to yield 8-alkylquinolines with linear alkyl substituents. The mechanism of the reaction was studied using deuterium labeling, kinetic isotope effect, and competition studies; the reaction may proceed through a five-membered metallacycle intermediate. Under similar conditions, an O-methyloxime derivative of (-)-santonin underwent regioselective alkylation with Et acrylate and acrylonitrile.
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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics