Recently I am researching about VINYLOGOUS ALDOL REACTION; ORGANOCATALYTIC MICHAEL ADDITION; MANNICH-TYPE REACTIONS; DIELS-ALDER REACTION; ALLYL ARYL KETONES; ASYMMETRIC-SYNTHESIS; GAMMA-BUTENOLIDES; CYCLIC-KETONES; ALPHA,BETA-UNSATURATED ALDEHYDES; 3-ALKYLIDENE OXINDOLES, Saw an article supported by the University of the Basque Country UPV/EHU [UFI QOSYC 11/22, GIU18/159]; Ministerio de Economia y Competitividad (MEC), Spain [CTQ2016-78487-C2]; MECEuropean Commission; Basque GovernmentBasque Government; European Funding Horizon 2020-MSCA [ITN-EJD CATMEC 14/06-721223]. Category: esters-buliding-blocks. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Urruzuno, I; Mugica, O; Zanella, G; Vera, S; Gomez-Bengoa, E; Oiarbide, M; Palomo, C. The CAS is 99-27-4. Through research, I have a further understanding and discovery of Dimethyl 5-aminoisophthalate
In this study, the unique capacity of bifunctional BrOnsted bases to generate alpha-branched ketone dienolates and control both site- and stereoselectivity of their addition reactions to representative classes of carbon electrophiles (i.e., vinyl sulfones, nitroolefins, formaldehyde) is documented. We demonstrate that by using selected chiral tertiary amine/squaramide catalysts, the reactions of beta,gamma-unsaturated cycloalkanones proceed through the dienolate C alpha almost exclusively and provide all-carbon quaternary cyclic ketone adducts in good yields with very high enantioselectivities. A minor amount (<5%) of gamma-addition is observed when nitroolefins are used as electrophiles. The parent acyclic ketone dienolates proved to be less reactive under these conditions, and thus still constitute a challenging class of substrates. Quantum chemical calculations correctly predict these differences in reactivity and explain the observed site-specificity and enantioselectivity. About Dimethyl 5-aminoisophthalate, If you have any questions, you can contact Urruzuno, I; Mugica, O; Zanella, G; Vera, S; Gomez-Bengoa, E; Oiarbide, M; Palomo, C or concate me.. Category: esters-buliding-blocks
Reference:
Patent; ASTRA ZENECA AB; NPS PHARMACEUTICALS, INC.; WO2004/14881; (2004); A2;,
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