Recently I am researching about MEMORY; PLASTICITY; CORTEX; AREA; DESIGN; RAT, Saw an article supported by the Guangzhou Science & Technology Project [2011Y2-00026, 201508020131]; Guangdong Science & technology Project [2014B050505016, 2013B050800009, 2013B040200031]; CAS Key Technology Talent Program China (2013). Published in SPRINGER BIRKHAUSER in NEW YORK ,Authors: Zhang, YM; Wang, YC; Guo, YP; Liao, JX; Tu, ZC; Lu, YZ; Ding, K; Tortorella, MD; He, JF. The CAS is 99-27-4. Through research, I have a further understanding and discovery of Dimethyl 5-aminoisophthalate. Quality Control of Dimethyl 5-aminoisophthalate
Recently, He et al. reported that CCKB receptors located in the neocortex of the brain when bound to their bound natural ligand, CCK peptides, enhance memory, bringing up the possibility that agonists targeting the CCKB receptor may act as therapeutic agents in diseases in which memory loss is marked as observed in dementia and Alzheimer’s. In this report, we describe the synthesis of novel low-molecular weight benzoamine CCKB receptor agonists. The compounds made in this series were determined to be mostly partial agonists, although some antagonists were identified, as well, capable of triggering calcium release in a cell line that overexpresses the CCKB receptor. Compound 35 demonstrated an EC50 of 0.15 mu M in the cell-based assay, but more importantly, several of the compounds, including 35, demonstrated a physiological effect, inducing long-term potentiation in rat brains comparable to the CCK-8 peptide albeit at much higher concentrations. Based on these findings, benzoamines may be the basis for a new series of CCKB receptor agonists in drug-discovery efforts that seek to develop therapeutics to prevent memory loss.
Quality Control of Dimethyl 5-aminoisophthalate. Bye, fridends, I hope you can learn more about C10H11NO4, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Patent; ASTRA ZENECA AB; NPS PHARMACEUTICALS, INC.; WO2004/14881; (2004); A2;,
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