Application In Synthesis of Methyl 3-phenyl-2-propenoate. Recently I am researching about PERMEABILITY, Saw an article supported by the Sichuan Science and Technology Program [2019JDRC0074]; National Science and Technology Major Project of the Ministry of Science and Technology of China [2018Z-X09721004009-002]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M631071]. Published in PHARMACOTHERAPY GROUP in BENIN CITY ,Authors: Zhang, Q; Li, RL; Liu, J; Peng, W; Gao, YX; Wu, CJ; Pu, XF. The CAS is 103-26-4. Through research, I have a further understanding and discovery of Methyl 3-phenyl-2-propenoate
Purpose: To investigate by in silico screening the anti-inflammatory constituents of Cinnamomum cassia twigs. Methods: Information on the constituents of C. cassia twigs was retrieved from the online Traditional Chinese Medicines (TCM) database and literature. Inflammation-related target proteins were identified from DrugBank, Online Mendelian Inheritance in Man (OMIM), Therapeutic Target Database (TTD), Genetic Association Database (GAD), and PharmGKB. The identified compounds were filtered by Lipinski’s rules with Discovery Studio software. The Libdock module was used to perform molecular docking; LibdockScores and default cutoff values for hydrogen bonds and van der Weals interactions were recorded. LibdockScores between the prototype ligand and target protein were set as the threshold; compounds with higher LibdockScores than threshold were regarded as active compounds. Cytoscape software was used to construct active constituent-target protein interaction networks. Results: Sixty-nine potential inflammatory constituents with good drug-like properties in C. cassia twigs were screened in silico based on molecular docking and network pharmacology analysis. JAK2, mPEGS-1, COX-2, IL-1 beta, and PPAR gamma were considered the five most important target proteins. Compounds such as methyl dihydromelilotoside, hierochin B, dihydromelilotoside, dehydrodiconiferyl alcohol, balanophonin, phenethyl (E)-3-[4-methoxyphenyl]-2-propenoate, quercetin, and luteolin each interacted with more than six of the selected target proteins. Conclusion: C. cassia twigs possess active compounds with good drug-like properties that can potentially be developed to treat inflammation with multi-components on multi-targets.
About Methyl 3-phenyl-2-propenoate, If you have any questions, you can contact Zhang, Q; Li, RL; Liu, J; Peng, W; Gao, YX; Wu, CJ; Pu, XF or concate me.. Application In Synthesis of Methyl 3-phenyl-2-propenoate
Reference:
Article; Weng, Shiue-Shien; Ke, Chih-Shueh; Chen, Fong-Kuang; Lyu, You-Fu; Lin, Guan-Ying; Tetrahedron; vol. 67; 9; (2011); p. 1640 – 1648;,
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