Application In Synthesis of Methyl 3-phenylpropionate. I found the field of Chemistry very interesting. Saw the article Catalytic asymmetric synthesis of 2,5-dihydrofurans using synergistic bifunctional Ag catalysis published in 2019.0, Reprint Addresses Chapman, E (corresponding author), Univ Arizona, Coll Pharm, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA.; Hu, WH (corresponding author), Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China.. The CAS is 103-25-3. Through research, I have a further understanding and discovery of Methyl 3-phenylpropionate.
We report a bifunctional Ag catalyst promoted intramolecular capture of oxonium ylides with alkynes for the enantioselective synthesis of 2,5-dihydrofurans. This represents unprecedented synergistic catalysis of a bifunctional Ag catalyst. Mechanistic studies revealed that [(R)-3,5-DM-BINAP](AgSbF6)(2) (9) is likely to be the active catalytic species and that the reaction involves second order kinetics with respect to 9, suggesting that two molecules of 9 are involved in the intramolecular trapping of a Ag-associated oxonium ylide with a Ag-activated alkyne. Based on our mechanistic hypothesis, we further optimized the reaction, rendering a facile approach to 2,5-dihydrofurans in good to excellent yields in a highly chemo- and enantioselective fashion.
Application In Synthesis of Methyl 3-phenylpropionate. About Methyl 3-phenylpropionate, If you have any questions, you can contact Shi, TD; Teng, SH; Reddy, AGK; Guo, X; Zhang, YT; Moore, KT; Buckley, T; Mason, DJ; Wang, W; Chapman, E; Hu, WH or concate me.
Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics