I found the field of Chemistry very interesting. Saw the article Design, Synthesis and Structure-Activity Relationships of Plant-Based 2-Aryl-3,4-dihydroisoquinolin-2-iums as Potential Antifungal Agents published in 2019. Safety of Dimethyl 5-aminoisophthalate, Reprint Addresses Chen, W (corresponding author), Southwest Jiaotong Univ, Sch Lifer Sci & Engn, Chengdu 610031, Sichuan, Peoples R China.. The CAS is 99-27-4. Through research, I have a further understanding and discovery of Dimethyl 5-aminoisophthalate
In order to discover more potent antifungal, a series of 2-aryl-3,4-dihydroisoquinolin-2-iums were reasonable designed and productive synthesized by introducing benzoic acid and phenol pharmacophores into the 2-position of isoquinoline. Their structures were identified by NMR and HRMS. The preliminary in vitro antifungal results showed that most of the title compounds exhibited moderate to significant inhibitory activities against various phytopathogenic fungi at 50 mu g.mL(-1), and were equal to controls (chlorothalonil, carbendazim). The concentration of 50% inhibition rate (EC50]) of 2-(3-ethoxycarbonyl-phenyl)-3,4-dihydroisoquinolin-2-ium (4j) against R. solani was 3.8495 mu g.mL(-1), which was significantly superior to chlorothalonil (4.6328 mu g.mL(-1)). All the EC50 values of 5 compounds (7.4583 similar to 15.4495 mu g.mL(-1)) against R. cerealis were better than chlorothalonil (16.0137 mu g.mL(-1)), and 2-(4-methoxycarbonylphenyl)-3,4-dihydroisoquinolin-2-ium (4f) is the best one. The present results provide valuable information for development of plant-based antifungal agents.
Safety of Dimethyl 5-aminoisophthalate. About Dimethyl 5-aminoisophthalate, If you have any questions, you can contact Chen, W; Zuo, HL; Li, YX; Liu, J; Zhou, XL or concate me.
Reference:
Patent; ASTRA ZENECA AB; NPS PHARMACEUTICALS, INC.; WO2004/14881; (2004); A2;,
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