Recommanded Product: Dimethyl 5-aminoisophthalate. Urruzuno, I; Mugica, O; Zanella, G; Vera, S; Gomez-Bengoa, E; Oiarbide, M; Palomo, C in [Urruzuno, Inaki; Mugica, Odei; Zanella, Giovanna; Vera, Silvia; Gomez-Bengoa, Enrique; Oiarbide, Mikel; Palomo, Claudio] Univ Pais Vasco UPV EHU, Dept Quim Organ 1, Manuel Lardizabal 3, San Sebastian 20018, Spain published alpha-Branched Ketone Dienolates: Base-Catalysed Generation and Regio- and Enantioselective Addition Reactions in 2019, Cited 137. The Name is Dimethyl 5-aminoisophthalate. Through research, I have a further understanding and discovery of 99-27-4.
In this study, the unique capacity of bifunctional BrOnsted bases to generate alpha-branched ketone dienolates and control both site- and stereoselectivity of their addition reactions to representative classes of carbon electrophiles (i.e., vinyl sulfones, nitroolefins, formaldehyde) is documented. We demonstrate that by using selected chiral tertiary amine/squaramide catalysts, the reactions of beta,gamma-unsaturated cycloalkanones proceed through the dienolate C alpha almost exclusively and provide all-carbon quaternary cyclic ketone adducts in good yields with very high enantioselectivities. A minor amount (<5%) of gamma-addition is observed when nitroolefins are used as electrophiles. The parent acyclic ketone dienolates proved to be less reactive under these conditions, and thus still constitute a challenging class of substrates. Quantum chemical calculations correctly predict these differences in reactivity and explain the observed site-specificity and enantioselectivity. Recommanded Product: Dimethyl 5-aminoisophthalate. About Dimethyl 5-aminoisophthalate, If you have any questions, you can contact Urruzuno, I; Mugica, O; Zanella, G; Vera, S; Gomez-Bengoa, E; Oiarbide, M; Palomo, C or concate me.
Reference:
Patent; ASTRA ZENECA AB; NPS PHARMACEUTICALS, INC.; WO2004/14881; (2004); A2;,
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