Recently I am researching about C-H BONDS; ELECTRON-TRANSFER OXIDATION; ALKYL RADICALS; COMPLEXES; ANION; FUNCTIONALIZATION; DERIVATIVES; MECHANISM; DISCOVERY; LIGANDS, Saw an article supported by the National Institute of General Medical Sciences (NIGMS), the NIH [R01 GM078201-05]; Princeton University, E. Taylor and the Taylor family. Computed Properties of C10H12O2. Published in NATURE PUBLISHING GROUP in LONDON ,Authors: Sarver, PJ; Bacauanu, V; Schultz, DM; DiRocco, DA; Lam, YH; Sherer, EC; MacMillan, DWC. The CAS is 103-25-3. Through research, I have a further understanding and discovery of Methyl 3-phenylpropionate
The introduction of a trifluoromethyl (CF3) group can dramatically improve a compound’s biological properties. Despite the well-established importance of trifluoromethylated compounds, general methods for the trifluoromethylation of alkyl C-H bonds remain elusive. Here we report the development of a dual-catalytic C(sp(3))-H trifluoromethylation through the merger of light-driven, decatungstate-catalysed hydrogen atom transfer and copper catalysis. This metallaphotoredox methodology enables the direct conversion of both strong aliphatic and benzylic C-H bonds into the corresponding C(sp(3))-CF3 products in a single step using a bench-stable, commercially available trifluoromethylation reagent. The reaction requires only a single equivalent of substrate and proceeds with excellent selectivity for positions distal to unprotected amines. To demonstrate the utility of this new methodology for late-stage functionalization, we have directly derivatized a broad range of approved drugs and natural products to generate valuable trifluoromethylated analogues. Preliminary mechanistic experiments reveal that a ‘Cu-CF3’ species is formed during this process and the critical C(sp(3))-CF3 bond-forming step involves the copper catalyst.
About Methyl 3-phenylpropionate, If you have any questions, you can contact Sarver, PJ; Bacauanu, V; Schultz, DM; DiRocco, DA; Lam, YH; Sherer, EC; MacMillan, DWC or concate me.. Computed Properties of C10H12O2
Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
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