Synthetic Route of 13671-00-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13671-00-6, name is Methyl 2,6-difluorobenzoate, This compound has unique chemical properties. The synthetic route is as follows.
a) Methyl 2-JZUORO-6-PHENOXYBENZOATE Methyl 2,6-difluorobenzoate (2 g), phenol (1.09 g), caesium carbonate (3.79 g), and dimethylformamide (10 mL) were loaded in a 100 mL round bottom flask and the resulting suspension heated to 80C for 6 h. After cooling the reaction to room temperature, water (30 mL) was added and the mixture extracted with dichloromethane (2 x 30 mL). The combined organic extracts were washed with brine (30 mL), dried (magnesium sulphate), filtered and evaporated in vacuo. The residue was purified by column chromatography (Silica: DICHLOROMETHANE/HEXANE 5: 2) to give the titled compound as a clear oil (1.7 g)
The chemical industry reduces the impact on the environment during synthesis Methyl 2,6-difluorobenzoate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; ASTRAZENECA AB; WO2004/113303; (2004); A1;,
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