Reference of 676621-95-7,Some common heterocyclic compound, 676621-95-7, name is Ethyl 3-(4-fluorophenyl)-2,2-dimethylpropanoate, molecular formula is C13H17FO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation of3- (4-fluorophenyl)-2, 2- dimethylpropionic acid A mixture of 3- (4-fluorophenyl)-2, 2-dimethylpropionic acid ethyl ester (10.0 g, 44.6 mmol, see Part 1 of Example 25a) and a solution of sodium hydroxide (25 g) in water (110 mL) was heated at refluxfor 18 h and cooled to room temperature. The solution was stirred on an ice bath and acidified with, concentrated aqueous hydrochloric acid. The resulting precipitate was collected by filtration, washed with water and dried under vacuum. The residue was stirred with dichloromethane and filtered, and the filtrate was concentrated to provide an off-white solid (7.60 g, 87%). OH NMR (300 mHz, CDC13) 6 7.14 (m, 2H), 6.98 (t, J = 9 Hz, 2H), 2.88 (s, 2H), 1.22 (s, 6H); mass spec (ES-) m/z 195.2 (100%,M-H+).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 3-(4-fluorophenyl)-2,2-dimethylpropanoate, its application will become more common.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2005/48932; (2005); A2;,
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