Some common heterocyclic compound, 1215205-50-7, name is Ethyl 1-(4-bromophenyl)cyclopropanecarboxylate, molecular formula is C12H13BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 1215205-50-7
l-(4-Bromo-phenyl)-cyclopropanecarboxylic acid ethyl ester (3.6g, 13.4mmol), bis(pinacolato)diboron (3.37g, 16. lmmol), and potassium acetate (2.8g, 29mmol) were combined in 1,4-dioxane (3OmL). The solution was purged with N2 for 10 minutes, and then (l,l’-bis(diphenylphosphino)ferrocene)- dichloropalladium(II) (0.5Og, 0.65mmol) was added and the reaction was heated to 8O0C for 2 hours. Aqueous work-up, followed by silica gel chromatography (0-30% EtOAc in hexanes), gave the title compound.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1215205-50-7, its application will become more common.
Reference:
Patent; AMIRA PHARMACEUTICALS, INC.; HUTCHINSON, John Howard; SEIDERS, Thomas Jon; WANG, Bowei; ARRUDA, Jeannie M.; ROPPE, Jeffrey Roger; PARR, Timothy; WO2010/141761; (2010); A2;,
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