These common heterocyclic compound, 178312-47-5, name is Ethyl 4,4-difluorocyclohexanecarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 178312-47-5
Step 5 4,4-Difluoro-cyclohexanecarboxylic acid: A solution of 4,4-difluoro-cyclohexanecarboxylic acid ethyl ester (970 mg, 5.0 mmol) in ethanol (5 mL) was treated with 2N sodium hydroxide (3.8 mL, 7.6 mmol) at 0 C., and the mixture was allowed to warm to ambient temperature and stirred for an additional 18 hours. The mixture was diluted with water (15 mL), and the pH was adjusted to 3-4 with 6 N hydrochloric acid. The mixture was extracted with toluene, dried and concentrated to give the title compound as a white solid. Yield: 758 mg (92%). 1H-NMR (CDCl3.) delta: 1.60-2.23 (m, 8H), 2.45 (m, 1H).
The synthetic route of Ethyl 4,4-difluorocyclohexanecarboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Auspex Pharmaceuticals, Inc.; US2008/146605; (2008); A1;,
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