Electric Literature of 14064-10-9, The chemical industry reduces the impact on the environment during synthesis 14064-10-9, name is Diethyl 2-chloromalonate, I believe this compound will play a more active role in future production and life.
MDPD was synthesized according to a procedure described by Shipp et al. Briefly, NaH (1.24 g, 0.0520 mol) was suspended in THF (10 mL) and cooled to 0° C. using an ice bath. A solution of diphenylamine (3.38 g, 0.0200 mol) in DMSO (18 mL) and THF (9 mL) was added and stirred for 1 h at 0° C. Carbon disulfide (2.84 mL, 0.0472 mol) was added and the solution stirred for a further 30 min at 0° C. The solution was then cooled using an ethylene glycol/CO2 bath prior to the addition of diethyl chloromalonate (3.23 mL, 0.0200 mol) and further stirring for 2 h at room temperature. Any remaining NaH was hydrolyzed with methanol and the product was extracted with diethyl ether. Volatiles were then removed and the product was purified using a silica column (ethyl acetate:hexane mix 10:90 to remove diphenylamine impurity, followed by 30:70 to elute product). The product was dried under vacuum to yield a yellow solid (yield 72percent).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diethyl 2-chloromalonate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ARROWHEAD MADISON INC.; Wakefield, Darren H.; Rossi, Nicholas A.; Sheik, Dan; US2013/121954; (2013); A1;,
Ester – Wikipedia,
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