Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5445-17-0, name is Methyl 2-bromopropanoate, A new synthetic method of this compound is introduced below., Product Details of 5445-17-0
The 2.50g (9.05mmol) of tert-butyl 2 – [(benzylamino) methyl] azetidine-1-carboxylate [racemate] was dissolved in dichloromethane (150ml), the 5.55ml (4.03g, 39.8mmol) of triethylamine and 3.04ml (4.53g, 27.1mmol) of methyl 2-bromo-propionate [racemate] was added and the mixture was stirred overnight at room temperature. Was added 5.55ml (4.03g, 39.8mmol) of triethylamine and 3.04ml (4.53g, 27.1mmol) of methyl 2-bromopropionate [racemate], and the mixture was stirred overnight at 40 . Then additional 5.55ml (4.03g, 39.8mmol) of triethylamine and 3.04ml (4.53g, 27.1mmol) of methyl 2-bromopropionate [racemate], and the mixture was at 40 overnight with stirring. After cooling to room temperature, the mixture was diluted with dichloromethane and washed with water, and the phases were separated. The aqueous phase was extracted twice with dichloromethane and the combined organic phase was washed with saturated aqueous sodium chloride, dried over sodium sulfate, filtered, and then the solvent was removed under reduced pressure. The crude product obtained was purified as follows: silica gel chromatography (dichloromethane, then dichloromethane / methanol = 100: 1). Yield: 3.22g (94%, based on the theoretical value).
The synthetic route of 5445-17-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Bayer Pharma Aktiengesellschaft; Allerheiligen, S.; Buchmuller, A.; Engel, K.; Gerdes, C.; Gericke, K. M.; Gerisch, M.; Heitmeier, S.; Hillisch, A.; Kinzel, T.; Lienau, P.; Riedl, B.; Rohrig, S.; Schmidt, M. V.; Strassburger, J.; Tersteegen, A.; (223 pag.)CN105408331; (2016); A;,
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