14064-10-9, name is Diethyl 2-chloromalonate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C7H11ClO4
Step 3; d3-2-(2-Methoxyphenoxy)propanedioic acid diethyl ester: 2-d3-methoxyphenol (5.9 g, 46 mmol) in ethanol (6 mL) and diethylchloromalonate (11.64 g, 60 mmol) in ethanol (6 mL) were sequentially added to a suspension of sodium methoxide (2.76 g, 51 mmol) in 60 mL of absolute ethanol. Under continuous stirring, the mixture was heated at reflux for about 25 hours, then cooled and maintained at ambient temperature for about 4 days. The reaction mixture was filtered and the filtrate was concentrated. The crude product, a yellow oil, was isolated using standard extractive work up and purified by column chromatography on silica gel to yield 9.1 g of the title compound (69percent yield). 1H NMR (300 MHz, CDCl3) delta 1.31 (t, J=7.2 Hz, 6H), 4.32 (q, J=7.2 Hz, 4H), 5.24 (s, 1H), 6.90 (m, 2H), 7.04 (m, 2H); E1-MS m/z=285 (M+). Step 3 d3-2-(2-Methoxyphenoxy)propanedioic acid diethyl ester: The title compound is made by following the procedure set forth in Example 3, step 3.
The synthetic route of 14064-10-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AUSPEX PHARMACEUTICALS, INC.; US2008/242687; (2008); A1;,
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