Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14064-10-9, name is Diethyl 2-chloromalonate, A new synthetic method of this compound is introduced below., Safety of Diethyl 2-chloromalonate
General procedure: To a stirred solution of 2 (2 mmol) and 3 (2 mmol) in 10 mL of CH2Cl2was added 0.24 mL of isoquinoline (2 mmol) dropwise at 10 8Cover 5 min. The reaction mixture was then allowed to warm toroom temperature and stand for 12 h. The solvent was removedunder reduced pressure, and the residue was purified by silica gel(Merck 230?240 mesh) column chromatography using n-hexane/EtOAc (3:1) mixture as eluent to afford the pure product.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Piltan, Mohammad; Yavari, Issa; Moradi, Loghman; Chinese Chemical Letters; vol. 24; 11; (2013); p. 979 – 983;,
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