These common heterocyclic compound, 29823-21-0, name is Ethyl 8-Bromooctanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C10H19BrO2
General procedure: 2,6-dichloro-9H-purine (5 mmol) or intermediates 5 was dissolved in 20 mL anhydrous DMF, then K2CO3 (8 mmol) was added, and ethyl 4-bromobutanoate or ethyl 8-bromooctanoate(8 mmol) was dropped into the solution. Cut off from the air, the solution was stirred at room temperature for overnight,and then adjusted to pH 7-8 with HCl (1 mol/L), then extracted with 50 mL ×3 ethyl acetate and the organic phase was combined, and washed with brine, dried over MgSO4 and evaporated. The crude product was purified by chromatography on a silica gel column (EtOAc/petroleum ether, 1 : 1) to give desired compounds 6a-6p.
The synthetic route of Ethyl 8-Bromooctanoate has been constantly updated, and we look forward to future research findings.
Reference:
Article; Xu, Zhaoxing; Yang, Yongchao; Mai, Xi; Liu, Bin; Xiong, Yuanzhen; Feng, Lihuang; Liao, Yijing; Zhang, Yu; Wang, Huanlu; Ouyang, Leiting; Liu, Shuhao; Chemical and Pharmaceutical Bulletin; vol. 66; 4; (2018); p. 439 – 451;,
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