Synthetic Route of 454-31-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 454-31-9, name is Ethyl 2,2-difluoroacetate, This compound has unique chemical properties. The synthetic route is as follows.
To a suspension of LiAlH4 in THF ( (97%, 3.96 g, 101.2 mmol, 200 mL) was addedethyl 2,2-difluoroacetate (24.76 g, 199.5 mmol) dropwise at -10 C. After addition, the reactionmixture was continued to stir for 1 h, then adjusted to pH= 2~3 with 2 M HCl solution. The resulting mixture was distilled and collected distillation at 90~96 oc to give the title compoundas colorless oil (7.30 g, yield 44.6%).1H NMR (400MHz, CDCb) 8 (ppm): 5.85 (tt, J = 55.7, 3.8 Hz, 1H), 3.81 (td, J = 14.5, 3.8 Hz,2H);19F NMR (376 MHz, CDCb) 8 (ppm): -127.90.
The chemical industry reduces the impact on the environment during synthesis Ethyl 2,2-difluoroacetate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; DAI, Weilong; XI, Ning; LI, Minxiong; ZHANG, Tao; LI, Xiaobo; HU, Haiyang; CHEN, Wuhong; WANG, Tingjin; LIU, Jun; (188 pag.)WO2017/48675; (2017); A1;,
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