Electric Literature of 5616-81-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5616-81-9 name is tert-Butyl 2-(methylamino)acetate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of alkylaminosulphonylphenylmethyl bromide (50 mg, 0.142 mmol) in DMF (5 mL) was added tert-butyl sarcosine (75 mg, 0.4 mmol) and cesium carbonate (100 mg, 0.28 mmol). The reaction was allowed to stir at room temperature overnight before it was poured into water and extracted with CH2CL2. The organic layer was washed with brine, dried over MGS04 and the solvent was removed in vacuo. Eluting through a solid phase extraction tube (5G) with 5% ethyl acetate/hexanes afforded the product (21 mg, 36%) 1H-NMR (CDC13) 8 : 7.93 (s, 1H) 7.52 (d, 1H), 7.47 (d, 1H) 3.88 (s, 2H), 3.24 (s, 2H), 2.99 (t, 4H), 2.42 (s, 3H), 1.53-1. 61 (m, 4H), 1.45 (s, 9H), 1.39-1. 42 (m, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl 2-(methylamino)acetate, and friends who are interested can also refer to it.
Reference:
Patent; ASTRAZENECA; NPS PHARMACEUTICALS, INC.; WO2004/92135; (2004); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics