The important role of

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 403-33-8, name is Methyl 4-fluorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of Methyl 4-fluorobenzoate

Example 7; Methyl 9-(3,5-dichloro-4-pyridylcarbamoyl)-6-methoxydibenzo[6,«f]furan-2- carboxylate; Step 1: Methyl-(4-fluoro-3-Bromo) benzoate; EPO Methyl-(4-fluoro) benzoate (28 g, 181.81 mmoles) was added to mixture sulphuric acid (93.63 ml) and water (1.6 ml) then bromine (8.4 ml, 163.63 mmoles) was added at O0C followed by addition of silver sulphate (51.02 g, 163.63 mmoles) .Reaction was stirred for 24 h. at room temperature. Reaction mass was poured in ice cold water (250 ml) and extracted with diethyl ether ( 100 x 3 ml) , dried and concentrated under reduced pressure to yield pale yellow liquid (36 g).1H nmr (300 MHz, DMSOd6): delta 3.86 (s, 3H), 7.54 (t, IH), 7.98-8.04 (m, IH), 8.19- 8.22 (dd, IH, J= 6.6 Hz).IR(KBr) cm4: 3098, 3052, 2847, 1727, 1599, 1507, 1492, 1436, 1389, 1282, 1226, 1107, 1048, 860, 763, 608.

The synthetic route of 403-33-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; KHAIRATKAR-JOSHI, Neelima; WO2006/51390; (2006); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics