Adding a certain compound to certain chemical reactions, such as: 88709-17-5, name is Ethyl 2-ethoxy-4-methylbenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 88709-17-5, name: Ethyl 2-ethoxy-4-methylbenzoate
To the reaction kettle were added ethyl 4-methyl-2-ethoxybenzoate (2.08 g, 10 mmol), ethanol (23 g, 0.50 mol), tetrahydrofuran (100 mL), and tert-peroxybutyl ether (1.75 g, 10 mmol) in this order. , PdCl2 (54.3 mg, 0.3 mmol) and 1,2-bis (di-2-pyridylphosphine) ethane (123.3 mg, 0.3 mmol), charged with 2.0 MPa of CO, heated to reflux, and stirred for 20 hours. After cooling to room temperature, a 2 mol / L sodium hydroxide aqueous solution (30 mL) was added to the reaction solution after depressurization. After stirring for 6 hours, cyclohexane (50 mL × 3) was added to wash the reaction solution. The reaction solution was neutralized with hydrochloric acid to a pH of 7, The solution was concentrated under pressure to about 50 mL, hydrochloric acid was acidified to pH 3, a yellow solid was precipitated, and the residue was recrystallized from toluene-petroleum ether to obtain a white solid intermediate (I) (1.94 g, yield: 76.9%).
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Reference:
Patent; Hangzhou China-USA East China Pharmaceutical Co., Ltd.; Yu Rui; Hong Xuming; Zheng Min; Shao Qingling; (8 pag.)CN110483292; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics