Electric Literature of 1150566-27-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1150566-27-0, name is Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1,2,3,4-10 tetrahydroquinoline (Intermediate C,700 mg,2. 67mmo ),ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate (600 mg,2.67 mmol)and K3P04 (1.69 g,7.98 mmol)in 2-methyl-2-butanol (10 mL)was added methanesulfonato(2-dicyclohexylphosphino-2′,4′,6′-tri-i-propyl-1,1’biphenyl)(2′-amino-1,1′-biphenyl-2-yl)palladium(II)(225 mg,0.27 mmol). The mixture washeated to 95 C for 12 h under an argon atmosphere. After cooling the reaction to room15 temperature,the mixture was filtered and concentrated in vacuo. The crude residue was purifiedby Prep-TLC (petroleum ether I EtOAc = 1 : 1)to give the title compound (110 mg,9%)asyellow oil. LCMS M/Z (M+H)453
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; CYR, Patrick; BRONNER, Sarah; ROMERO, F. Anthony; MAGNUSON, Steven; TSUI, Vickie Hsiao-Wei; WAI, John; LAI, Kwong Wah; WANG, Fei; (251 pag.)WO2017/205536; (2017); A2;,
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