3-Sep-2021 News Some tips on 23426-63-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-bromo-2-methylpropanoate, its application will become more common.

Electric Literature of 23426-63-3,Some common heterocyclic compound, 23426-63-3, name is Methyl 2-bromo-2-methylpropanoate, molecular formula is C5H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1st step will be to make the resultant of 9 H – xanthene -9 – thione with 2 – methyl butyrate […], Cu powder/CuBr, PMDETA in accordance with the molar ratio of 1:2: 2:2 uniformly mixed, using toluene as the solvent is placed in the branch pipe flask, nitrogen atmosphere sealing thaw 3 degas. Then in the 65 C oil bath reaction 48 h. After the reaction taken out, alumina column chromatography out metal and salt, silica gel column chromatography to remove organic impurities, there will be phase turns on lathe does, get the pure target product VI, and the yield is 70%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-bromo-2-methylpropanoate, its application will become more common.

Reference:
Patent; Beijing University of Chemical Technology; Wang Li; Wang Shichao; Shao Jianwei; Yu Haoyu; Yang Wantai; Chen Dong; Ma Yuhong; (21 pag.)CN107522686; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics