Application of 4630-80-2,Some common heterocyclic compound, 4630-80-2, name is Methyl cyclopentanecarboxylate, molecular formula is C7H12O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A 50-mL glass reactor was charged under dry argon at 0 C with 15 mL of THF, and 20 mmol of magnesium powder, 20 mmol of EtAlCl2, and 1.0 mmol of Cp2TiCl2 were added in succession under stirring. After 1 h, 10 mmol of symmetrical acetylene and 20 mmol of ester were added, and the mixture was heated to 60 C and stirred for 6 h at that temperature. When the reaction was complete, the mixture was cooled to 0 C in a stream of argon, 10-15 mL of diethyl ether was added, and the mixture was hydrolyzed with 5 % aqueous HCl. The organic layer was separated, the aqueous layer was extracted with two portions of diethyl ether, and the combined extracts were washed with a solution of NaHCO3 until neutral washings and dried over MgSO4. The product was isolated by vacuum distillation.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl cyclopentanecarboxylate, its application will become more common.
Reference:
Article; Khafizova; Shaibakova; Chobanov; Gubaidullin; Tyumkina; Dzhemilev; Russian Journal of Organic Chemistry; vol. 51; 9; (2015); p. 1277 – 1281; Zh. Org. Khim.; vol. 51; 9; (2015); p. 1303 – 1307,5;,
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