Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 75567-84-9, name is Methyl 3-(4-bromophenyl)propanoate, A new synthetic method of this compound is introduced below., Product Details of 75567-84-9
According to the following scheme, electrochromic compound 8 was synthesized.The flask was charged with the above intermediate 2-1 (3.92 g, 10 mmol), methyl 3- (4-bromophenyl) propionate (4.86 g, 20 mmol), sodium tert-butoxide (3.84 g, 40 mmol), palladium (67 mg, 0.3 mmol), and tri-tert-butylphosphonium tetrafluoroborate (261 mg, 0.9 mmol), and after purging with argon gas, ortho-xylene (40 mL) degassed with argon gas was added, And the mixture was heated and stirred at 115 C. for 3 hours. The reaction solution was returned to room temperature and filtered through Celite. Next, the filtrate was concentrated and purified by silica gel column chromatography (stationary phase: neutral silica gel, mobile phase: toluene) to obtain Intermediate 8-1 as a pale yellow solid (yield 5.23 g , Yield 73%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; RICOH COMPANY LIMITED; GOTO, DAISUKE; SAGISAKA, TOSHIYA; YAMAMOTO, SATOSHI; KANEKO, FUMINARI; INOUE, MAMIKO; YASHIRO, TOHRU; YUTANI, KEIICHIRO; NAGAI, KAZUKIYO; SHIMADA, TOMOYUKI; SHINODA, MASATO; (45 pag.)JP2016/138067; (2016); A;,
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