In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 23426-63-3, name is Methyl 2-bromo-2-methylpropanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: esters-buliding-blocks
Step B; 4-Mercapto-2,5-dimethyl-phenol 44 obtained in step A above is dissolved in acetonitrile (30 mL). Powdered cesium carbonate (7.06 g, 21.7 mmol) is added, followed by 2-bromo-2-methyl-propionic acid methyl ester (2.40 mL, 18.5 mmol). The mixture is stirred at rt for 2 h. Filtration and concentration, followed by silica gel chromatography (0-50% ethyl acetate in hexanes) yielded 2-(4-hydroxy-2,5-dimethyl-phenylsulfanyl)-2-methyl- propionic acid methyl ester 45 (0.45 g, 13%) as a white waxy solid: 1H-NMR (400 MHz, CDCl3) delta = 7.17 (s, IH)3 6.65 (s, IH), 5.06 (s, IH), 3.67 (s, 3H), 2.36 (s, 3H), 2.17 (s, 3H), 1.47 (s, 6H). MS calcd. for C13H19O3S (M+H1) 255.1, found 255.1.
The synthetic route of 23426-63-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IRM LLC; WO2007/56496; (2007); A1;,
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