Related Products of 383-62-0, The chemical industry reduces the impact on the environment during synthesis 383-62-0, name is Ethyl 2-chloro-2,2-difluoroacetate, I believe this compound will play a more active role in future production and life.
To a mixture of (2S,3R,4R,5S,6R)-2-(5-(bicyclo[4.2.0]octa-1 (6),2,4-trien- 3-ylmethyl)-4-chloro-2-hydroxyphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran- 3,4,5-triol (Compound No.8) (260 mg, 0.64 mmol) in N,N-dimethylformamide (3.0 ml) with CS2CO3 (416 mg, 1.28 mmol) was added ethyl 2-chloro-2,2- difluoroacetate (151 mg, 0.95 mmol). The reaction mixture was stirred at room temperature for overnight, then purified by chromatography on a C18 reversed phase column to yield the title compound as a white solid. 1 H NMR(400 MHz, CD3OD) delta 7.47 (s, 1H), 7.23 (s, 1H), 7.04 (d, J = 7.6 Hz, 1H), 6.93 (d, J = 7.6 Hz, 1H), 6.88 (s, 1H), 6.75 (t, J = 72.4 Hz, 1H), 4.48 (d, J = 9.6 Hz, 1H), 4.03-4.12 (m, 2 H), 3.88 (d, J = 12.0 Hz, 1H), 3.64 – 3.68 (m, 1H), 3.45 – 3.56 (m, 2 H), 3.35 – 3.42 (m, 2 H), 3.13 (s, 4 H); MS (ES) m/z: 474.1 [M+NH4]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-chloro-2,2-difluoroacetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; GAUL, Micheal; KUO, Gee-Hong; XU, Guozhang; LIANG, Yin; (218 pag.)WO2018/89449; (2018); A1;,
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