Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 18595-18-1, name is Methyl 3-amino-4-methylbenzoate, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Methyl 3-amino-4-methylbenzoate
Methyl-3-amino-4-methyl benzoate (50 g), cyanamide (42 g) was added to ethanol (300 rnL) in a round bottom flask at 25-35C. Concentrated hydrochloric acid (21.2 mL) was added to the reaction mass in a drop-wise manner at 25-35C under nitrogen atmosphere. The reaction mass was heated to 80-85C and, stirred for 6 hours. Then thereaction mass was concentrated under vacuum at less than 50C, then cooled to25-35C. Water (350 mL) was added to the reaction mass, cooled to 0-5C and stirred for 15 mins. Aqueous sodium nitrate solution (51.5 gin 135 ml of DM water) was added to the reaction mass at 0-5C in 45 rnins. The precipitate formed was filtered, washed with DM water, acetone followed by methyl tert-butylether (MTBE), and dried undervacuum at 50-55C to provide the title compound (47.5 g).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 18595-18-1.
Reference:
Patent; LAURUS LABS PRIVATE LIMITED; CHAVA, Satyanarayana; GORANTLA, Seeta Rama Anjaneyulu; INDUKURI, Venkata Sunil Kumar; MOTURU, Venkata Rama Krishna Murthy; JAMJANAM, Srivardhana Rao; SELA, Venkata Purushottama Siva Prasad; WO2015/87343; (2015); A2;,
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