Reference of 32122-09-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 32122-09-1, name is Ethyl 2-(benzyloxy)acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
In a reaction flask, lithium hexamethyldisilazide (LiHMDS, 1 M in toluene, 330 L, 0.33 mol) was charged followed by addition of anhydrous THF (400 mL). The solution was cooled down to -70 C. gamma-Butyrolactone (28.4 g, 0.33 mol) was added dropwise while the temperature of the reaction was kept at no more than 60 C. Ethyl benzyloxyacetate (50.0 g, 0.26 mol, formula XI, R1 = benzyl, R6 = ethyl) was added dropwise. After the addition, the reaction mixture was stirred at -60 C for 10 min. Ice-cold water (65 mL) was added, followed by addition of concentrated HCl to pH 3. The mixture was warmed to room temperature and the organic layer was collected. The aqueous layer was extracted with ethyl acetate (4×60 mL). The combined organic layers were evaporated and the residue was purified by flash column chromatography to afford 40.0 g (52% yield, based on gamma-butyrolactone) of a compound of formula II, wherein R1 is benzyl.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-(benzyloxy)acetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Lonza Ltd; The designation of the inventor has not yet been filed; EP2634180; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics