Reference of 56741-34-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56741-34-5 name is Methyl 5-amino-2-fluorobenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture solution of 5-amino-2-fiuoro-benzoic acid methyl ester (26 g, 153.8 mmol), 3- bromo-benzaldehyde (28.5 g, 153.8 mmol) and -toluenesulfonic acid (590 mg, 3.2 mmol) in toluene (200 mL) was heated to reflux for 12 hours. Then the reaction mixture was cooled to room temperature. The solvent was removed in vacuo and the residue was washed with ether to afford 5- [(3-bromo-benzylidene)-amino] -2-fiuoro-benzoic acid methyl ester (51.7 g, quant.) as a pale-white solid: MS calcd. for Ci5HiiBrFlN02 337.16, obsd. (ESI+) [(M+H)+] 336.0 & 338.0.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 5-amino-2-fluorobenzoate, and friends who are interested can also refer to it.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; CHEN, Li; FENG, Lichun; HUANG, Mengwei; LIU, Yongfu; WU, Guolong; WU, Jim, Zhen; ZHOU, Mingwei; WO2011/128251; (2011); A1;,
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