In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 609-12-1, name is Ethyl 2-bromo-3-methylbutanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of Ethyl 2-bromo-3-methylbutanoate
A solution of pyrazine-2-carbothioamide (1 g, 7.19 mmol) in ethanol (10 ml) was treated with ethyl 2-bromoisovalerate (2.25 g, 10.8 mmol), and pyridine (853 mg, 872 mul, 10.8 mmol) is combined to give a dark brown suspension. and heated to 100 C. for 6 hours in a sealed tube. The reaction mixture was cooled and concentrated to dryness under reduced pressure, and the resulting suspension is extracted with ethyl acetate (3*50 mL). The organic layers were combined, washed with saturated NaHCO3 (1*50 mL), saturated sodium chloride (2*20 mL). The organic layers were dried over MgSO4 and concentrated in vacuo to give 5-isopropyl-2-pyrazin-2-yl-thiazol-4-ol (260 mgs, 16%) which was used directly without further purification.
The synthetic route of 609-12-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Alam, Muzaffar; Du Bois, Daisy Joe; Hawley, Ronald Charles; Kennedy-Smith, Joshua; Minatti, Ana Elena; Palmer, Wylie Solang; Silva, Tania; Wilhelm, Robert Stephen; US2011/71150; (2011); A1;,
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